Centre for Antibiotic Allergy and Research @ Austin Health

Department of Infectious Diseases, Austin Health - 145 Studley Road Heidelberg, Melbourne, VIC 3084, Australia



Antibiotic allergy testing and translational allergy diagnostics

Antibiotic allergy testing and translational allergy diagnostics

Antibiotic allergy testing and translational allergy diagnosticsAntibiotic allergy testing and translational allergy diagnosticsAntibiotic allergy testing and translational allergy diagnostics

Latest Publications


Latest publications from CAAR affiliated authors

1. Meher-Homji Z, Tam CS, Siderov J, Seymour JF, Holmes NE, Chua KYL, Phillips EJ, Slavin MA, Trubiano JA.  High prevalence of antibiotic allergies in cladribine-treated patients with hairy cell leukemia - lessons for immunopathogenesis and prescribing.  Leuk Lymphoma. 2019 Jul 1:1-6. doi: 10.1080/10428194.2019.1633640 

2.  Trubiano JA, Slavin MA, Thursky KA, Grayson ML, Phillips EJ.  Beta-Lactam and Sulfonamide Allergy Testing Should Be a Standard of Care in Immunocompromised Host.  J Allergy Clin Immunol Pract. 2019 Jun 13. pii: S2213-2198(19)30547-1. doi: 10.1016/j.jaip.2019.05.051 

3.  Devchand M, Kirkpatrick CMJ, Stevenson W, Garrett K, Perera D, Khumra S, Urbancic K, Grayson ML, Trubiano JA.  Evaluation of a pharmacist-led penicillin allergy de-labelling ward round: a novel antimicrobial stewardship intervention.  J Antimicrob Chemother. 2019 Jun 1;74(6):1725-1730. doi: 10.1093/jac/dkz082. 

4. Konvinse KC, Trubiano JA, Pavlos R, et al.  HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms.  J Allergy Clin Immunol. 2019 Jul;144(1):183-192. doi: 10.1016/j.jaci.2019.01.045. 

5.  Redwood A, Trubiano J, Phillips EJ.  Prevention and Diagnosis of Severe T-Cell-Mediated Adverse Drug Reactions: Are We There Yet?  J Allergy Clin Immunol Pract. 2019 Jan;7(1):228-230. doi: 10.1016/j.jaip.2018.07.011.  

6. Phillips EJ, Bigliardi P, Bircher AJ, Broyles A, Chang YS, Chung WH, Lehloenya R, Mockenhaupt M, Peter J, Pirmohamed M, Roujeau JC, Shear NH, Tanno LK, Trubiano J, Valluzzi R, Barbaud A. Controversies in drug allergy: Testing for delayed reactions. J Allergy Clin Immunol. 2018 Nov 30. pii: S0091-6749(18)31569-0

7. Blumenthal KG, Peter JG, Trubiano JA, Phillips EJ. Antibiotic allergy. Lancet. 2018 Dec 14. pii: S0140-6736(18)32218-9. doi: 10.1016/S0140-6736(18)32218-9

8. Trubiano JA, Smibert O, Douglas A, Devchand M, Lambros B, Holmes NE, Chua KY, Phillips EJ, Slavin MA. The Safety and Efficacy of an Oral Penicillin Challenge Program in Cancer Patients: A Multicenter Pilot Study. Open Forum Infect Dis. 2018 Nov 17;5(12):ofy306. doi: 10.1093/ofid/ofy306. 

9. Moran R, Devchand M, Smibert O, Trubiano JA. Antibiotic allergy labels in hospitalised and critically ill adults: a review of current impacts of inaccurate labelling. Antibiotic allergy labels in hospitalised and critically ill adults: a review of current impacts of inaccurate labelling.

10. Trubiano JA, Keith C, Devchand M, Garrett K. The global implications of the gentamicin histamine contamination- sorting fact from fiction. Antimicrob Agents Chemother. 2018 Nov 26. pii: AAC.02053-18. doi: 10.1128/AAC.02053-18

11. Trubiano JA, Douglas AP, Goh M, Slavin MA, Phillips EJ. The Safety of Antibiotic Skin Testing in Severe T-cell-Mediated Hypersensitivity of immunocompetent and immunocompromised hosts. J Allergy Clin Immunol Pract. 2018 Sep 25. pii: S2213-2198(18)30590-7. doi: 10.1016/j.jaip.2018.09.014. 

12. Kwong JC, Urbancic K, Trubiano JA. Beyond penicillin - rapid desensitization for specific flucloxacillin hypersensitivity. Antimicrob Agents Chemother. 2018 Sep 17. pii: AAC.01371-18

13. Devchand M, Urbancic K, Khumra S, Douglas A, Smibert O, Cohen E, Sutherland M, Phillips EJ, Trubiano JA. Pathways to Improved Antibiotic Allergy and Antimicrobial Stewardship Practice - The Validation of a Beta-Lactam Antibiotic Allergy Assessment Tool. J Allergy Clin Immunol Pract. 2018 Aug 29

14. Trubiano JA, Grayson ML, Phillips EJ, Stewardson AJ, Thursky KA, Slavin MA. Antibiotic allergy testing improves antibiotic appropriateness in patients with cancer. J Antimicrob Chemother. 2018 Jul 27

15. Urbancic KF, Pisasale D, Wight J, Trubiano JA. Dapsone safety in hematology patients: Pathways to optimizing Pneumocystis jirovecii pneumonia prophylaxis in hematology malignancy and transplant recipients. Transpl Infect Dis. 2018 Jul 21:e12968.

16. Trubiano JA, Grayson ML, Thursky KA, Phillips EJ, Slavin MA. How antibiotic allergy labels may be harming our most vulnerable patients. Med J Aust. 2018 Jun 18;208(11):469-470.

17. White KD, Abe R, Ardern-Jones M, Beachkofsky T, Bouchard C, Carleton B, Chodosh J, Cibotti R, Davis R, Denny JC, Dodiuk-Gad RP, Ergen EN, Goldman JL, Holmes JH 4th, Hung SI, Lacouture ME, Lehloenya RJ, Mallal S, Manolio TA, Micheletti RG, Mitchell CM, Mockenhaupt M, Ostrov DA, Pavlos R, Pirmohamed M, Pope E, Redwood A, Rosenbach M, Rosenblum MD, Roujeau JC, Saavedra AP, Saeed HN, Struewing JP, Sueki H, Sukasem C, Sung C, Trubiano JA, Weintraub J, Wheatley LM, Williams KB, Worley B, Chung WH, Shear NH, Phillips EJ. SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation. J Allergy Clin Immunol Pract. 2018 Jan - Feb;6(1):38-69

18. Trubiano JA, Strautins K, Redwood AJ, Pavlos R, Konvinse KC, Aung AK, Slavin MA, Thursky KA, Grayson ML, Phillips EJ. The Combined Utility of Ex vivo IFN-γ Release Enzyme-Linked ImmunoSpot Assay and In vivo Skin Testing in Patients With Antibiotic-Associated Severe Cutaneous Adverse Reactions. J Allergy Clin Immunol Pract. 2017 Oct 31

19. Trubiano JA, Stone CA, Grayson ML, Urbancic K, Slavin MA, Thursky KA, Phillips EJ. The 3 Cs of Antibiotic Allergy-Classification, Cross-Reactivity, and Collaboration. J Allergy Clin Immunol Pract. 2017 Nov - Dec;5(6):1532-1542

20. Trubiano JA, Adkinson NF, Phillips EJ. Penicillin Allergy Is Not Necessarily Forever. JAMA. 2017 Jul 4;318(1):82-83

21. Trubiano JA, Thursky KA, Stewardson AJ, Urbancic K, Worth LJ, Jackson C, Stevenson W, Sutherland M, Slavin MA, Grayson ML, Phillips EJ. Impact of an Integrated Antibiotic Allergy Testing Program on Antimicrobial Stewardship: A Multicenter Evaluation. Clin Infect Dis. 2017 Jul 1;65(1):166-174.

22. Konvinse KC, Phillips EJ, White KD, Trubiano JA. Old dog begging for new tricks: current practices and future directions in the diagnosis of delayed antimicrobial hypersensitivity. Curr Opin Infect Dis. 2016 Dec;29(6):561-576.

23. Trubiano JA, Redwood A, Strautins K, Pavlos R, Woolnough E, Chang CC, Phillips E. Drug-specific upregulation of CD137 on CD8+ T cells aids in the diagnosis of multiple antibiotic toxic epidermal necrolysis. J Allergy Clin Immunol Pract. 2017 May - Jun;5(3):823-826

24. Trubiano JA, Aung AK, Nguyen M, Fehily SR, Graudins L, Cleland H, Padiglione A, Peleg AY. A Comparative Analysis Between Antibiotic- and Nonantibiotic-Associated Delayed Cutaneous Adverse Drug Reactions. J Allergy Clin Immunol Pract. 2016 Nov - Dec;4(6):1187-1193. doi: 10.1016/j.jaip.2016.04.026. Epub 2016 Jun 7.

25. Goldblatt C, Khumra S, Booth J, Urbancic K, Grayson ML, Trubiano JA. Poor reporting and documentation in drug-associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis - Lessons for medication safety. Br J Clin Pharmacol. 2017 Feb;83(2):224-226. 

26. Trubiano JA, Chen C, Cheng AC, Grayson ML, Slavin MA, Thursky KA; National Antimicrobial Prescribing Survey (NAPS). Antimicrobial allergy 'labels' drive inappropriate antimicrobial prescribing: lessons for stewardship. J Antimicrob Chemother. 2016 Jun;71(6):1715-22. 

27. Trubiano J, Phillips E. Antimicrobial stewardship's new weapon? A review of antibiotic allergy and pathways to 'de-labeling'. Curr Opin Infect Dis. 2013 Dec;26(6):526-37.