Centre for Antibiotic Allergy and Research @ Austin Health

Department of Infectious Diseases, Austin Health - 145 Studley Road Heidelberg, Melbourne, VIC 3084, Australia

+61394964572

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Antibiotic allergy testing and translational allergy diagnostics

Antibiotic allergy testing and translational allergy diagnostics

Antibiotic allergy testing and translational allergy diagnosticsAntibiotic allergy testing and translational allergy diagnosticsAntibiotic allergy testing and translational allergy diagnostics

Resources - Antibiotic Allergy Assessment Tools & Fact Sheet

Adapted from validated antibiotic allergy assessment tool from Devchand et al.  J Allergy Clin Immunol Pract. 2019 Mar;7(3):1063-1065.e5  

VicTag Antibiotic Allergy Assessment Tool (pdf)

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Austin Antibiotic Allergy Assessment Tool_generic (pdf)

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Penicillin Allergy Assessment Guide - Therapeutic Guidelines and CAAR (tif)

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Resources - Articles, guidelines & practical videos

Protocol for Oral Pencillin Rechallenge - Trubiano et al. Open Forum Infections Diseases 2018 (pdf)

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Beta-lactam allergy clinic testing algorithm - Adapted Trubiano et al Clin Infect Dis. 2017 Jul 1;65(1):166-174 (pdf)

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Approach to trimethroprim-sulfamethoxazole allergy - Adapated from Urbancic et al Transpl Infect Dis. 2018 Jul 21:e12968 (pdf)

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Current Opinion Article - Antibiotic Allergy in Antimicrobial Stewardship Review 2013 (pdf)

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Journal of Allergy & Clinical Immunology In Practice Article - Antibiotic Allergy Cross-Reactivity Review 2017 (pdf)

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Current Opinion Article - T-cell Mediated Hypersensitivity Review Article (pdf)

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How to perform intradermal testing video (mp4)

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How to perform skin prick testing (mp4)

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Resources - Consumer Information

Additional Consumer Information Sheets created in partnership with NCAS are available at  - https://www.ncas-australia.org/education

10 Golden Rules of Penicillin Allergy

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INTRODUCTION

The "10 Golden Rules of Penicillin Allergy" were put together by #SoMe via @twitter and the "penicillin allergy family". They were posted on the @CAAR_AUS site and reproduced here.

  

  1. Do not label a patient as penicillin allergic if they have not had a reaction to penicillin (e.g. family history only) @PAallergy
  2. Do not label a patient as penicillin allergic if they report a known drug side effect (e.g. vomiting, diarrhoea) @TrubianoJason
  3. Do not automatically label a patient that is penicillin allergic also allergic to cephalosporins @TracyZembles @drdavidwjg
  4. Do not label a patient allergic to a beta-lactam class (e.g. penicillins) - name the implicated drug (e.g. amoxicillin) @ABsteward
  5. Do not label as penicillin allergic if a rash to penicillin or amoxicillin occurred during mononucleosis (i.e. EBV) @TanyaLaidlawMD
  6. Penicillin allergy is rarely forever @KimberlyBlumen1
  7. Penicillin allergy should always be investigated @EricMacyMD
  8. Penicillin allergy in the EMR should include the allergy type, timing, severity and tolerated antibiotics @julie_justo
  9. A change in a patient’s penicillin allergy "label" needs to be conveyed to the patient, provider and referrer @marylynnstaicu
  10. Usual rules of penicillin cross-reactivity do not apply to severe cutaneous adverse reactions (e.g. SJS, TEN, DRESS) @peripatetical