Centre for Antibiotic Allergy and Research @ Austin Health

Department of Infectious Diseases, Austin Health - 145 Studley Road Heidelberg, Melbourne, VIC 3084, Australia



Antibiotic allergy testing and translational allergy diagnostics

Resources - Antibiotic Allergy Assessment Tools & Fact Sheet

Adapted from validated antibiotic allergy assessment tool from Devchand et al.  J Allergy Clin Immunol Pract. 2019 Mar;7(3):1063-1065.e5  

VicTag Antibiotic Allergy Assessment Tool (pdf)


Austin Antibiotic Allergy Assessment Tool_generic (pdf)


Penicillin Allergy Assessment Guide - Therapeutic Guidelines and CAAR (tif)


Resources - Articles, guidelines & practical videos

Protocol for Oral Pencillin Rechallenge - Trubiano et al. Open Forum Infections Diseases 2018 (pdf)


Beta-lactam allergy clinic testing algorithm - Adapted Trubiano et al Clin Infect Dis. 2017 Jul 1;65(1):166-174 (pdf)


Approach to trimethroprim-sulfamethoxazole allergy - Adapated from Urbancic et al Transpl Infect Dis. 2018 Jul 21:e12968 (pdf)


Current Opinion Article - Antibiotic Allergy in Antimicrobial Stewardship Review 2013 (pdf)


Journal of Allergy & Clinical Immunology In Practice Article - Antibiotic Allergy Cross-Reactivity Review 2017 (pdf)


Current Opinion Article - T-cell Mediated Hypersensitivity Review Article (pdf)


How to perform intradermal testing video (mp4)


How to perform skin prick testing (mp4)


Resources - Consumer Information

Additional Consumer Information Sheets created in partnership with NCAS are available at  - https://www.ncas-australia.org/education

10 Golden Rules of Penicillin Allergy



The "10 Golden Rules of Penicillin Allergy" were put together by #SoMe via @twitter and the "penicillin allergy family". They were posted on the @CAAR_AUS site and reproduced here.


  1. Do not label a patient as penicillin allergic if they have not had a reaction to penicillin (e.g. family history only) @PAallergy
  2. Do not label a patient as penicillin allergic if they report a known drug side effect (e.g. vomiting, diarrhoea) @TrubianoJason
  3. Do not automatically label a patient that is penicillin allergic also allergic to cephalosporins @TracyZembles @drdavidwjg
  4. Do not label a patient allergic to a beta-lactam class (e.g. penicillins) - name the implicated drug (e.g. amoxicillin) @ABsteward
  5. Do not label as penicillin allergic if a rash to penicillin or amoxicillin occurred during mononucleosis (i.e. EBV) @TanyaLaidlawMD
  6. Penicillin allergy is rarely forever @KimberlyBlumen1
  7. Penicillin allergy should always be investigated @EricMacyMD
  8. Penicillin allergy in the EMR should include the allergy type, timing, severity and tolerated antibiotics @julie_justo
  9. A change in a patient’s penicillin allergy "label" needs to be conveyed to the patient, provider and referrer @marylynnstaicu
  10. Usual rules of penicillin cross-reactivity do not apply to severe cutaneous adverse reactions (e.g. SJS, TEN, DRESS) @peripatetical